I. Radioisotope Generator, RG
A. Cyclotron – Charged particles (H- ion) in
magnetic field accelerated by a rapidly varying electric field outwards from
the center along a spiral path as a particle accelerator
l Model – PETtrace 10
l Manufacturer – GE Healthcare System
l Introduction – 2011. 07.
l Accelerating Particle – Proton, Deuteron
l Energy – Proton 16.5 MeV, Deuteron
8.4 MeV
l Beam Output Current – 100 µA
l Ion Source Type – H-, D-
l Target Positions – 6 Targets (18F,
13N, 15O, 64Cu, 124I, 11CO2)
l Beam Extraction – Carbon Foil
B. 68Ge/68Ga Generator - A device used to extract the positron-emitting isotope 68Ga
from a source of decaying 68Ge. The parent isotope 68Ge
has a half of 271 days and can be easily utilized for in-hospital production of
generator produced 68Ga.
lI. Radiopharmaceutical
Synthesizer
A. GEFastlabTM 2
synthesizer
l FastlabTM 2 is a compact automated system that converts
externally produced radio-isotopes(from cyclotron) into radiochemicals ready
for further processing and quality control
l Radiopharmaceuticals
[18F]FDG (Phosphate, Duo Citrate) / [18F]NaF
/ [18F]FMISO / [18F]FLT
B. GE Tracerlab MX (Only Use for
Cassette type)
l Radiopharmaceuticals
[18F]FDG / [18F]FDOPA / [18F]NaF
/ [18F]FMISO / [18F]FLT
C. GE Tracerlab FX-FN (Only use for research)
Ø [18F]FCH / [18F]FDOPA / [18F]FTHA /
[18F]FMISO / [18F]FLT
D. GE Tracerlab FXc Pro
l FXc Pro is a compact, automated radiochemistry system, which will
produce C-11 labeled radiochemicals from [11C]MeI or [11C]MEOTf
l Radiopharmaceuticals
[11C]Methionine / [11C]Raclopride
/ [11C]FMZ / [11C]PIB / [11C]Acetate / [11C]ABP688
/ [11C]PBR28 / [11C]DASB / [11C]PK11195 / [11C]Sertraline
/ [11C]Verapamil
E. Soild Target Processing System
ALCEO
l Radioisotope
[62Zn] / [64Cu] / [89Zr]
/ [124I]
F. N-13 Ammonia Process Unit
l Radiopharmaceutical
[13N]Ammonia
G. O-15 Water Process Unit
l Radiopharmaceutical
Ø [15O]Water
H. Ga-68 Process Unit (SNUH in
House)
l Radiopharmaceuticals
Ø [68Ga]NOTA-TOC / [68Ga]NOTA-RGD
3. Quality Control
All quality controls completed before patient
injection except for sterility test
Ø Appearance
Ø Filter Integrity Test(FIT SNUH in
House)
Ø Bacterial Endotoxin Test(PTS)
Ø Kryptofix2.2.2 Spot Test
Ø pH(pH Meter or pH Paper)
Ø Radiochemical Purity(TLC)
Ø Energy Spectrum(MCA)
Ø Residual Solvent(GC)
Ø Half-Life Determination(Dose
Calibrator)
ØSterility Test(FTM, TSB)
4. Analytical Equipment
A. High Performance Liquid Chromatography(HPLC)
Ø Model – HPLC System
Ø Manuf. – Gilson, Inc.
Ø Introduction – 2011.
Ø Pump – Binary
Ø Detector – 155 UV/VIS, NaI
Scintillation(Raytest)
Ø Prep 3EA, Anal 3EA
B. Gas Chromatography(GC)
Ø Model – 7820A GC System
Ø Manuf. – Agilent Technologies
Ø Introduction – 2011.
Ø Detector – FID
Ø 2EA
C. Thin Layer Chromatography(TLC)
Ø Model – AR-2000-1
Ø Manuf. – Bioscan, Inc.
Ø Introduction – 2014.
Ø Detector – P10 Gas-Filled
Proportional Counter
Ø 2EA
D. Portable Testing System(Endosafe®-PTS™)
Ø Model – Endosafe® PTS
KINETIC READER
Ø Manuf. – Charles River Laboratories
Ø Introduction – 2011.
Ø Sensitivity – 5~0.05 EU/mL
Ø 2EA
E. Filter Integrity Tester
Ø Model – Filter Integrity tester
Ø Manuf. – SNUH in-house
Ø Introduction – 2016.
Ø 1EA
F. Multi-Channel Analyzer(MCA)
Ø Model – GenieTM 2000
Spectroscopy
Ø Manuf. – CANBERRA Industries, Inc.
Ø Introduction – 2014.
Ø Detector – High Performance Germanium
Ø 1EA