PET | Evaluation of Normal Distribution of 18F-Florbetaben at Whole Body Ja…

Department of Nuclear Medicine, Seoul National University Hospital, Korea

Purpose: 18F-florbetaben is one of a radiopharmaceutical to diagnosis a dementia in neurological nuclear medicine, because this is accumulated at amyloidosis neuron cell caused dementia in brain. By the way, amyloidosis is a rare disease that results from the buildup of misfolded proteins known as amyloids at whole body. So, in this paper, we will evaluate a normal distribution of 18F-florbetaben at various organ of whole body.

Materials & Methods: We injected 18F-florbetaben (8.1±1.4mCi) to Alzheimer disease patients (n=10, age:

78.5±12) who had a normal finding of PET. After 90minutes later, we acquired PET date of not only brain but whole body using Biograph mCT40 (Siemens, German). After reconstruction PET data applied with time of fight and point spread function, we classify a various organs into two groups as accumulated organs and excretory organs. And we set ROIs and calculated an average SUV of each organ.

Results: In case of  18F-florbetaben accumulated organs, an average SUV of gray matter, white mater, salivary gland, myocardium, T-spine, liver, pancreas, renal cortex, sternum and muscle are 2.24, 0.92, 3.00,

1.43, 3.23, 4.00, 1.58, 1.77, 2.89, and 1.05. In case of excretory organs, an average SUV of gall bladder, large bowl, and bladder are 60.00, 12.40, and 35.89

Conclusions: 18F-florbetaben is one of kind beta-amyloid that will accumulate at amyloidosis. Using this mechanism like result, we can standardize a distribution of 18F-Florbetaben at normal organ. Therefore, if

18F-Florbetaben is used at a whole body PET, those normal SUV will help for diagnosis of amyloidosis resulting in specific areas.

Keywords: 18F-Florbetaben, distribution, whole body, amyloidosis.