Gamma | RELATIONSHIP BETWEEN BRAIN SPECT IMAGE PROCESSING AND SPM RESULT
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작성자 : 서울대 핵의학과 작성일2016-11-24 조회2,972회관련링크
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연도 : 2006
RELATIONSHIP BETWEEN BRAIN SPECT IMAGE PROCESSING AND SPM RESULT.
Byung Jin Kim, Jin Eui Kim, Jae Ryong Woo, Kyu Chin Cho.
Department of Nuclear medicine, Seoul National University Hospital, Seoul, Korea.
[Purporse]
The aim of this study is to determine whether statistical parametric mapping(SPM) result could be affected by filter cut-off frequency and attenuation correction in brain single photon emission tomography(SPECT) image processing.
[Methods & Materials]
The brain SPECT scans were performed for 15 children(11boys and 4 girls; mean age: 9.7±3.6 years) with attention deficit hyperactivity disorder. Tc-99m-hexamethyl-propylene-amine-oxime(HMPAO) was given intravenously with pediatric dose of 11.1 MBq/kg. Environmental stimuli such as light and noise were controlled, particularly at the time of Tc-99m-HMPAO intravenous injection.
The SPECT images were acquired on a triple head SPECT camera(Prism3000, Picker, Ohio, USA) with low energy high resolution fanbeam collimator and were reconstructed by filtered back projection with a Metz filter(cut-off frequency 0.25-0.45 cycles/pixel) and Chang's attenuation correction(edge threshold value 8±4). The pair sample t-test(uncorrected P<0.01) with SPM was used to analyze brain SPECT images. The control group consisted of 17 normal children(11 boys and 6 girls; mean age: 10.4±2.3 years).
[Result]
Areas of increased metabolism(AIM) analysed by SPM changed proportional to the filter cut-off frequency. Although the cut-off frequency and the edge threshold value for attenuation correction were changed, areas of decreased metabolism(ADM) showed no significant change compared with other SPM results.
[Conclusion]
We believe that ADM in SPM of brain SPECT still correlates the brain perfusion defect area even when the filter cut-off frequency and the edge threshold value for attenuation correction are changed. Key word : Brain SPECT, SPM, AIM, ADM.